Референсный код SAS Studio для расчета доверительных интервалов в перекрестном исследовании биоэквивалентности (2X2X2 crossover)

Для того что бы бы выполнить вычисление доверительных интервалов для перекрестносго исследования биоэквиваелнтности, проведенного по конвенциальному дизайну в двух периодах с двумя последовательностями в SAS применима процедура PROC GLM.

При разработке кода необходимо быть уверенным в том, что код функционирует надлежащим образом. Что бы убедиться в этом, после создания, а затем после внесения изменений следует выполнять валидацию кода относительно референсных датасетов. Для валидации представленного кода были использованы датасеты описанные в статье Reference Datasets for 2-Treatment, 2-Sequence, 2-Period Bioequivalence Studies (Helmut Schütz, Detlew Labes, Anders Fuglsang). Указанный набор датасетов позволяет провести валидацию на широком спектре входящих данных и выявить большинство возможных ошибок.

Ядро используемого кода:

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PROC GLM data=pkdata;
CLASS Period Sequence Formulation Subject;
MODEL logCMAX = Sequence Subject(Sequence) Period Formulation/CLPARM ALPHA=0.1;
RANDOM Subject(Sequence) /TEST;
LSMEANS Formulation / PDIFF=control("R") CL ALPHA=0.1;
ESTIMATE 'T vs R' Formulation -1 1;
ods output LSMeanDiffCL=LSMeanDiffCL;
RUN;

Результаты валидации:

Dataset	Результат источника*	CI90% Lower**	Difference**	CI90% Upper**	Соответствует
A	95.09 (90.76, 99.62)	90.76203983	95.086158011	99.616287405	Да
B	71.10 (51.45, 98.26)	51.449065786	71.100494336	98.257960909	Да
C	58.56 (39.41, 87.03)	39.407700872	58.562933761	87.029111946	Да
D	71.10 (51.45, 98.26)	51.449065786	71.100494336	98.257960909	Да
E	91.83 (55.71, 151.37)	55.710249623	91.829819642	151.36740245	Да
F	99.89 (93.37, 106.86)	93.37224183	99.889649689	106.86197439	Да
G	92.15 (88.46, 95.99)	88.460367814	92.150242368	95.994029625	Да
H	93.42 (86.81, 100.55)	86.805401143	93.423157096	100.54542882	Да

*Результат округлен до 2х знаков после запятой

**Результат представлен без округления

Код может показаться несколько избыточным, но демонстрирует неколько подходов к получению необходимых данных от PROC GLM.

Datasets A-F

proc datasets lib=work nolist;
delete result;
run;

DATA pkdata;
infile datalines dlm=" " truncover;
input Subject $ Sequence $ Period $ Formulation $ Cmax;
logCMAX=log(Cmax);
datalines;
1 RT 1 R 181.09
2 RT 1 R 114.48
3 TR 1 T 225.95
4 RT 1 R 176.91
5 TR 1 T 147.01
6 TR 1 T 97.53
7 RT 1 R 146.60
8 TR 1 T 45.58
9 RT 1 R 109.20
10 RT 1 R 125.61
11 TR 1 T 92.26
12 RT 1 R 237.95
13 TR 1 T 145.46
14 TR 1 T 179.96
15 TR 1 T 173.86
16 RT 1 R 144.00
17 RT 1 R 185.10
18 TR 1 T 117.99
1 RT 2 T 210.14
2 RT 2 T 98.72
3 TR 2 R 241.09
4 RT 2 T 186.65
5 TR 2 R 139.56
6 TR 2 R 124.77
7 RT 2 T 137.62
8 TR 2 R 57.71
9 RT 2 T 139.36
10 RT 2 T 120.43
11 TR 2 R 116.10
12 RT 2 T 228.63
13 TR 2 R 165.09
14 TR 2 R 181.09
15 TR 2 R 206.66
16 RT 2 T 143.25
17 RT 2 T 192.22
18 TR 2 R 125.50
;
RUN;

ods graphics off;
PROC GLM data=pkdata;
CLASS Period Sequence Formulation Subject;
MODEL logCMAX = Sequence Subject(Sequence) Period Formulation/CLPARM ALPHA=0.1;
RANDOM Subject(Sequence) /TEST;
LSMEANS Formulation / PDIFF=control("R") CL ALPHA=0.1;
ESTIMATE 'T vs R' Formulation -1 1;
ods output LSMeanDiffCL=LSMeanDiffCL;
RUN;

PROC APPEND base=result data=work.lsmeandiffcl;
RUN;

proc datasets lib=work nolist;
delete lsmeandiffcl;
run;

DATA pkdata;
infile datalines dlm=" " truncover;
input ObsN $ Subject $ Sequence $ Period $ Formulation $ Cmax;
logCMAX=log(Cmax);
datalines;
1 1 TR 1 T 2.52
2 2 TR 1 T 8.87
3 3 TR 1 T 0.79
4 4 TR 1 T 1.68
5 5 TR 1 T 6.95
6 6 TR 1 T 1.05
7 7 TR 1 T 0.99
8 8 TR 1 T 5.6
9 9 TR 1 T 3.16
10 1 TR 2 R 5.47
11 2 TR 2 R 4.84
12 3 TR 2 R 2.25
13 4 TR 2 R 1.82
14 5 TR 2 R 7.87
15 6 TR 2 R 3.25
16 7 TR 2 R 12.39
17 8 TR 2 R 4.77
18 9 TR 2 R 1.88
19 10 RT 1 R 4.98
20 11 RT 1 R 7.14
21 12 RT 1 R 1.81
22 13 RT 1 R 7.34
23 14 RT 1 R 4.25
24 15 RT 1 R 6.66
25 16 RT 1 R 4.76
26 17 RT 1 R 7.16
27 18 RT 1 R 5.52
28 10 RT 2 T 3.19
29 11 RT 2 T 9.83
30 12 RT 2 T 2.91
31 13 RT 2 T 4.58
32 14 RT 2 T 7.05
33 15 RT 2 T 3.41
34 16 RT 2 T 2.49
35 17 RT 2 T 6.18
36 18 RT 2 T 2.85
;
RUN;

PROC GLM data=pkdata;
CLASS Period Sequence Formulation Subject;
MODEL logCMAX = Sequence Subject(Sequence) Period Formulation/CLPARM ALPHA=0.1;
RANDOM Subject(Sequence) /TEST;
LSMEANS Formulation / PDIFF=control("R") CL ALPHA=0.1;
ESTIMATE 'T vs R' Formulation -1 1;
ods output LSMeanDiffCL=LSMeanDiffCL;
RUN;

PROC APPEND base=result data=work.lsmeandiffcl;
RUN;

proc datasets lib=work nolist;
delete lsmeandiffcl;
run;

DATA pkdata;
infile datalines dlm=" " truncover;
input ObsN $ Subject $ Sequence $ Period $ Formulation $ Cmax;
logCMAX=log(Cmax);
datalines;
1 1 TR 1 T 2.52
10 1 TR 2 R 5.47
4 4 TR 1 T 1.68
13 4 TR 2 R 1.82
5 5 TR 1 T 6.95
14 5 TR 2 R 7.87
7 7 TR 1 T 0.99
16 7 TR 2 R 12.39
19 10 RT 1 R 4.98
28 10 RT 2 T 3.19
20 11 RT 1 R 7.14
29 11 RT 2 T 9.83
21 12 RT 1 R 1.81
30 12 RT 2 T 2.91
22 13 RT 1 R 7.34
31 13 RT 2 T 4.58
23 14 RT 1 R 4.25
32 14 RT 2 T 7.05
24 15 RT 1 R 6.66
33 15 RT 2 T 3.41
25 16 RT 1 R 4.76
34 16 RT 2 T 2.49
26 17 RT 1 R 7.16
35 17 RT 2 T 6.18
27 18 RT 1 R 5.52
36 18 RT 2 T 2.85
;
RUN;

PROC GLM data=pkdata;
CLASS Period Sequence Formulation Subject;
MODEL logCMAX = Sequence Subject(Sequence) Period Formulation/CLPARM ALPHA=0.1;
RANDOM Subject(Sequence) /TEST;
LSMEANS Formulation / PDIFF=control("R") CL ALPHA=0.1;
ESTIMATE 'T vs R' Formulation -1 1;
ods output LSMeanDiffCL=LSMeanDiffCL;
RUN;

PROC APPEND base=result data=work.lsmeandiffcl;
RUN;

proc datasets lib=work nolist;
delete lsmeandiffcl;
run;

DATA pkdata;
infile datalines dlm=" " truncover;
input ObsN $ Subject $ Sequence $ Period $ Formulation $ Cmax;
logCMAX=log(Cmax);
datalines;
1 1 TR 1 T 2.52
10 1 TR 2 R 5.47
2 2 TR 1 T 8.87
11 2 TR 2 R 4.84
3 3 TR 1 T 0.79
12 3 TR 2 R 2.25
4 4 TR 1 T 1680000
13 4 TR 2 R 1820000
5 5 TR 1 T 6.95
14 5 TR 2 R 7.87
6 6 TR 1 T 1.05
15 6 TR 2 R 3.25
7 7 TR 1 T 0.99
16 7 TR 2 R 12.39
8 8 TR 1 T 5.6
17 8 TR 2 R 4.77
9 9 TR 1 T 3.16
18 9 TR 2 R 1.88
19 10 RT 1 R 4.98
28 10 RT 2 T 3.19
20 11 RT 1 R 7.14
29 11 RT 2 T 9.83
21 12 RT 1 R 1.81
30 12 RT 2 T 2.91
22 13 RT 1 R 7.34
31 13 RT 2 T 4.58
23 14 RT 1 R 4250000
32 14 RT 2 T 7050000
24 15 RT 1 R 6.66
33 15 RT 2 T 3.41
25 16 RT 1 R 4.76
34 16 RT 2 T 2.49
26 17 RT 1 R 7.16
35 17 RT 2 T 6.18
27 18 RT 1 R 5520000
36 18 RT 2 T 2850000
;
RUN;

PROC GLM data=pkdata;
CLASS Period Sequence Formulation Subject;
MODEL logCMAX = Sequence Subject(Sequence) Period Formulation/CLPARM ALPHA=0.1;
RANDOM Subject(Sequence) /TEST;
LSMEANS Formulation / PDIFF=control("R") CL ALPHA=0.1;
ESTIMATE 'T vs R' Formulation -1 1;
ods output LSMeanDiffCL=LSMeanDiffCL;
RUN;

PROC APPEND base=result data=work.lsmeandiffcl;
RUN;

proc datasets lib=work nolist;
delete lsmeandiffcl;
run;

DATA pkdata;
infile datalines dlm=" " truncover;
input ObsN $ Subject $ Sequence $ Period $ Formulation $ Cmax;
logCMAX=log(Cmax);
datalines;
1 1 TR 1 T 2.52
2 2 TR 1 T 8.87
3 3 TR 1 T 79.0
4 4 TR 1 T 1.68
5 5 TR 1 T 6.95
6 6 TR 1 T 1.05
7 7 TR 1 T 0.99
8 8 TR 1 T 5.6
9 9 TR 1 T 3.16
10 1 TR 2 R 5.47
11 2 TR 2 R 4.84
12 3 TR 2 R 2.25
13 4 TR 2 R 1.82
14 5 TR 2 R 7.87
15 6 TR 2 R 3.25
16 7 TR 2 R 12.39
17 8 TR 2 R 4.77
18 9 TR 2 R 1.88
19 10 RT 1 R 4.98
20 11 RT 1 R 7.14
21 12 RT 1 R 1.81
22 13 RT 1 R 7.34
23 14 RT 1 R 4.25
24 15 RT 1 R 6.66
25 16 RT 1 R 4.76
26 17 RT 1 R 7.16
27 18 RT 1 R 5.52
28 10 RT 2 T 3.19
29 11 RT 2 T 9.83
30 12 RT 2 T 2.91
31 13 RT 2 T 4.58
32 14 RT 2 T 7.05
33 15 RT 2 T 3.41
34 16 RT 2 T 2.49
35 17 RT 2 T 6.18
36 18 RT 2 T 2.85
;
RUN;

PROC GLM data=pkdata;
CLASS Period Sequence Formulation Subject;
MODEL logCMAX = Sequence Subject(Sequence) Period Formulation/CLPARM ALPHA=0.1;
RANDOM Subject(Sequence) /TEST;
LSMEANS Formulation / PDIFF=control("R") CL ALPHA=0.1;
ESTIMATE 'T vs R' Formulation -1 1;
ods output LSMeanDiffCL=LSMeanDiffCL;
RUN;

PROC APPEND base=result data=work.lsmeandiffcl;
RUN;

proc datasets lib=work nolist;
delete lsmeandiffcl;
run;

DATA pkdata;
infile datalines dlm=" " truncover;
input ObsN $ Subject $ Sequence $ Period $ Formulation $ Cmax;
logCMAX=log(Cmax);
datalines;
1 1 TR 1 T 4.34635
2 1 TR 2 R 4.45488
3 2 TR 1 T 3.22579
4 2 TR 2 R 1.78912
5 3 TR 1 T 1.46572
6 3 TR 2 R 2.55294
7 4 TR 1 T 4.05118
8 4 TR 2 R 4.58297
9 5 TR 1 T 3.65939
10 5 TR 2 R 2.12957
11 6 TR 1 T 1.40002
12 6 TR 2 R 2.14148
13 7 TR 1 T 3.67227
14 7 TR 2 R 4.58497
15 8 TR 1 T 4.04046
16 8 TR 2 R 2.53935
17 9 TR 1 T 1.46176
18 9 TR 2 R 1.79842
19 10 TR 1 T 3.2398
20 10 TR 2 R 4.46071
21 11 TR 1 T 4.33865
22 11 TR 2 R 2.98584
23 12 TR 1 T 1.64605
24 12 TR 2 R 1.55107
25 13 TR 1 T 2.78824
26 13 TR 2 R 4.22009
27 14 TR 1 T 4.5302
28 14 TR 2 R 3.43345
29 15 TR 1 T 1.93819
30 15 TR 2 R 1.41915
31 16 TR 1 T 2.35354
32 16 TR 2 R 3.88228
33 17 TR 1 T 4.59986
34 17 TR 2 R 3.84653
35 18 TR 1 T 2.31491
36 18 TR 2 R 1.41315
37 19 TR 1 T 1.97034
38 19 TR 2 R 3.47419
39 20 TR 1 T 4.54207
40 20 TR 2 R 4.19218
41 21 TR 1 T 2.7462
42 21 TR 2 R 1.53357
43 22 TR 1 T 1.66916
44 22 TR 2 R 3.02832
45 23 TR 1 T 4.36145
46 23 TR 2 R 4.44286
47 24 TR 1 T 3.19772
48 24 TR 2 R 1.77079
49 25 TR 1 T 1.474
50 25 TR 2 R 2.5802
51 26 TR 1 T 4.07237
52 26 TR 2 R 4.5786
53 27 TR 1 T 3.63348
54 27 TR 2 R 2.10594
55 28 TR 1 T 1.40039
56 28 TR 2 R 2.16552
57 29 TR 1 T 3.69786
58 29 TR 2 R 4.5886
59 30 TR 1 T 4.01878
60 30 TR 2 R 2.5123
61 31 TR 1 T 1.45421
62 31 TR 2 R 1.81731
63 32 TR 1 T 3.26777
64 32 TR 2 R 4.47204
65 33 TR 1 T 4.32293
66 33 TR 2 R 2.95752
67 34 TR 1 T 1.63117
68 34 TR 2 R 1.56332
69 35 TR 1 T 2.81634
70 35 TR 2 R 4.23823
71 36 TR 1 T 4.52169
72 36 TR 2 R 3.40612
73 37 TR 1 T 1.91716
74 37 TR 2 R 1.42377
75 38 TR 1 T 2.37955
76 38 TR 2 R 3.90577
77 39 TR 1 T 4.59923
78 39 TR 2 R 3.82237
79 40 TR 1 T 2.28942
80 40 TR 2 R 1.40978
81 41 TR 1 T 1.99218
82 41 TR 2 R 3.50117
83 42 TR 1 T 4.54938
84 42 TR 2 R 4.1731
85 43 TR 1 T 2.71828
86 43 TR 2 R 1.52247
87 44 TR 1 T 1.68509
88 44 TR 2 R 3.05664
89 45 TR 1 T 4.37611
90 45 TR 2 R 4.43039
91 46 TR 1 T 3.16958
92 46 TR 2 R 1.75285
93 47 TR 1 T 1.48275
94 47 TR 2 R 2.6076
95 48 TR 1 T 4.09322
96 48 TR 2 R 4.57374
97 49 TR 1 T 3.60737
98 49 TR 2 R 2.08259
99 50 TR 1 T 1.40127
100 50 TR 2 R 2.18981
101 51 RT 1 R 3.72324
102 51 RT 2 T 4.59172
103 52 RT 1 R 3.99678
104 52 RT 2 T 2.4854
105 53 RT 1 R 1.44714
106 53 RT 2 T 1.83657
107 54 RT 1 R 3.29565
108 54 RT 2 T 4.48291
109 55 RT 1 R 4.30679
110 55 RT 2 T 2.92921
111 56 RT 1 R 1.61672
112 56 RT 2 T 1.57601
113 57 RT 1 R 2.84451
114 57 RT 2 T 4.25597
115 58 RT 1 R 4.5127
116 58 RT 2 T 3.37866
117 59 RT 1 R 1.89648
118 59 RT 2 T 1.42888
119 60 RT 1 R 2.40575
120 60 RT 2 T 3.92898
121 61 RT 1 R 4.5981
122 61 RT 2 T 3.79794
123 62 RT 1 R 2.26415
124 62 RT 2 T 1.4069
125 63 RT 1 R 2.01434
126 63 RT 2 T 3.52799
127 64 RT 1 R 4.55621
128 64 RT 2 T 4.15366
129 65 RT 1 R 2.69044
130 65 RT 2 T 1.51183
131 66 RT 1 R 1.70143
132 66 RT 2 T 3.08493
133 67 RT 1 R 4.39035
134 67 RT 2 T 4.41748
135 68 RT 1 R 3.14139
136 68 RT 2 T 1.73531
137 69 RT 1 R 1.49198
138 69 RT 2 T 2.63512
139 70 RT 1 R 4.11373
140 70 RT 2 T 4.56838
141 71 RT 1 R 3.58107
142 71 RT 2 T 2.05953
143 72 RT 1 R 1.40265
144 72 RT 2 T 2.21437
145 73 RT 1 R 3.74839
146 73 RT 2 T 4.59435
147 74 RT 1 R 3.97447
148 74 RT 2 T 2.45867
149 75 RT 1 R 1.44056
150 75 RT 2 T 1.8562
151 76 RT 1 R 3.32344
152 76 RT 2 T 4.49331
153 77 RT 1 R 4.29024
154 77 RT 2 T 2.90093
155 78 RT 1 R 1.6027
156 78 RT 2 T 1.58914
157 79 RT 1 R 2.87272
158 79 RT 2 T 4.27332
159 80 RT 1 R 4.50323
160 80 RT 2 T 3.35108
161 81 RT 1 R 1.87615
162 81 RT 2 T 1.43448
163 82 RT 1 R 2.43214
164 82 RT 2 T 3.95189
165 83 RT 1 R 4.59648
166 83 RT 2 T 3.77327
167 84 RT 1 R 2.23912
168 84 RT 2 T 1.40452
169 85 RT 1 R 2.0368
170 85 RT 2 T 3.55464
171 86 RT 1 R 4.56255
172 86 RT 2 T 4.13385
173 87 RT 1 R 2.6627
174 87 RT 2 T 1.50166
175 88 RT 1 R 1.71818
176 88 RT 2 T 3.1132
177 89 RT 1 R 4.40414
178 89 RT 2 T 4.40412
179 90 RT 1 R 3.11316
180 90 RT 2 T 1.71816
181 91 RT 1 R 1.50168
182 91 RT 2 T 2.66275
183 92 RT 1 R 4.13389
184 92 RT 2 T 4.56254
185 93 RT 1 R 3.55459
186 93 RT 2 T 2.03676
187 94 RT 1 R 1.40453
188 94 RT 2 T 2.23916
189 95 RT 1 R 3.77331
190 95 RT 2 T 4.59648
191 96 RT 1 R 3.95185
192 96 RT 2 T 2.4321
193 97 RT 1 R 1.43447
194 97 RT 2 T 1.87618
195 98 RT 1 R 3.35113
196 98 RT 2 T 4.50325
197 99 RT 1 R 4.27329
198 99 RT 2 T 2.87267
199 100 RT 1 R 1.58912
200 100 RT 2 T 1.60272
;
RUN;

PROC GLM data=pkdata;
CLASS Period Sequence Formulation Subject;
MODEL logCMAX = Sequence Subject(Sequence) Period Formulation/CLPARM ALPHA=0.1;
RANDOM Subject(Sequence) /TEST;
LSMEANS Formulation / PDIFF=control("R") CL ALPHA=0.1;
ESTIMATE 'T vs R' Formulation -1 1;
ods output LSMeanDiffCL=LSMeanDiffCL;
RUN;

PROC APPEND base=result data=work.lsmeandiffcl;
RUN;

proc datasets lib=work nolist;
delete lsmeandiffcl;
run;

DATA result (drop=i j Dependent Difference _Formulation LowerCL UpperCL);
set result;
LowerCI = exp(LowerCL)*100;
Diff = exp(Difference)*100;
UpperCI = exp(UpperCL)*100;
RUN;

[свернуть]

Datasets G

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proc datasets lib=work nolist;
delete result;
run;

DATA pkdata;
infile datalines dlm=" " truncover;
input ObsN $ Subject $ Formulation $ Period $ Sequence $ Cmax;
logCMAX=log(Cmax);
datalines;
1 1 T 1 TR 168.406971
2 1 R 2 TR 210.919302
3 2 T 1 TR 131.030557
4 2 R 2 TR 67.431371
5 3 T 1 TR 151.736588
6 3 R 2 TR 85.12962
7 4 T 1 TR 375.575338
8 4 R 2 TR 147.501644
9 5 T 1 TR 50.022999
10 5 R 2 TR 20.010703
11 6 T 1 TR 185.146675
12 6 R 2 TR 35.799928
13 7 T 1 TR 587.468348
14 7 R 2 TR 37.402211
15 8 T 1 TR 144.208919
16 8 R 2 TR 101.714056
17 9 T 1 TR 136.093807
18 9 R 2 TR 38.71825
19 10 T 1 TR 152.131435
20 10 R 2 TR 62.823091
21 11 T 1 TR 108.381288
22 11 R 2 TR 109.279346
23 12 T 1 TR 394.97575
24 12 R 2 TR 48.489544
25 13 T 1 TR 231.583991
26 13 R 2 TR 85.289332
27 14 T 1 TR 381.700475
28 14 R 2 TR 137.728689
29 15 T 1 TR 253.503735
30 15 R 2 TR 471.986382
31 16 T 1 TR 191.845477
32 16 R 2 TR 134.573858
33 17 T 1 TR 104.103038
34 17 R 2 TR 157.743293
35 18 T 1 TR 69.353727
36 18 R 2 TR 56.295695
37 19 T 1 TR 130.15899
38 19 R 2 TR 55.903509
39 20 T 1 TR 72.949174
40 20 R 2 TR 151.363897
41 21 T 1 TR 58.094988
42 21 R 2 TR 112.780416
43 22 T 1 TR 264.356947
44 22 R 2 TR 44.187525
45 23 T 1 TR 179.653272
46 23 R 2 TR 164.924611
47 24 T 1 TR 86.224452
48 24 R 2 TR 135.473163
49 25 T 1 TR 84.136188
50 25 R 2 TR 81.371995
51 26 T 1 TR 285.259889
52 26 R 2 TR 39.442794
53 27 T 1 TR 62.94776
54 27 R 2 TR 27.681993
55 28 T 1 TR 235.506388
56 28 R 2 TR 77.015332
57 29 T 1 TR 390.663369
58 29 R 2 TR 88.328537
59 30 T 1 TR 120.493118
60 30 R 2 TR 173.324111
61 31 T 1 TR 111.596694
62 31 R 2 TR 78.931687
63 32 T 1 TR 158.648779
64 32 R 2 TR 151.862284
65 33 T 1 TR 329.994846
66 33 R 2 TR 50.841212
67 34 T 1 TR 350.636138
68 34 R 2 TR 67.259865
69 35 T 1 TR 332.622841
70 35 R 2 TR 97.307566
71 36 T 1 TR 243.856611
72 36 R 2 TR 47.113278
73 37 T 1 TR 153.605199
74 37 R 2 TR 59.27053
75 38 T 1 TR 147.857188
76 38 R 2 TR 132.689376
77 39 T 1 TR 103.785184
78 39 R 2 TR 114.532132
79 40 T 1 TR 133.067055
80 40 R 2 TR 51.618138
81 41 T 1 TR 161.160942
82 41 R 2 TR 43.599003
83 42 T 1 TR 237.253839
84 42 R 2 TR 122.033155
85 43 T 1 TR 161.275489
86 43 R 2 TR 39.952842
87 44 T 1 TR 67.579371
88 44 R 2 TR 40.759446
89 45 T 1 TR 242.157358
90 45 R 2 TR 181.071583
91 46 T 1 TR 79.226592
92 46 R 2 TR 110.111699
93 47 T 1 TR 137.963141
94 47 R 2 TR 68.21396
95 48 T 1 TR 37.985895
96 48 R 2 TR 44.611124
97 49 T 1 TR 116.333397
98 49 R 2 TR 49.860836
99 50 T 1 TR 179.71508
100 50 R 2 TR 54.845762
101 51 T 1 TR 208.527253
102 51 R 2 TR 77.6953
103 52 T 1 TR 197.790404
104 52 R 2 TR 387.71256
105 53 T 1 TR 106.746212
106 53 R 2 TR 64.236185
107 54 T 1 TR 304.717464
108 54 R 2 TR 64.451299
109 55 T 1 TR 93.296734
110 55 R 2 TR 68.059482
111 56 T 1 TR 80.841629
112 56 R 2 TR 273.69493
113 57 T 1 TR 107.647821
114 57 R 2 TR 110.74907
115 58 T 1 TR 59.997872
116 58 R 2 TR 116.531007
117 59 T 1 TR 91.760423
118 59 R 2 TR 207.829153
119 60 T 1 TR 58.681863
120 60 R 2 TR 128.265635
121 61 T 1 TR 91.900425
122 61 R 2 TR 85.526564
123 62 T 1 TR 170.110252
124 62 R 2 TR 36.666705
125 63 T 1 TR 113.270703
126 63 R 2 TR 134.149143
127 64 T 1 TR 194.339872
128 64 R 2 TR 147.257305
129 65 T 1 TR 403.204529
130 65 R 2 TR 68.466399
131 66 T 1 TR 121.761246
132 66 R 2 TR 50.135768
133 67 T 1 TR 98.679855
134 67 R 2 TR 156.526051
135 68 T 1 TR 209.223928
136 68 R 2 TR 50.994698
137 69 T 1 TR 144.705439
138 69 R 2 TR 61.959952
139 70 T 1 TR 172.905889
140 70 R 2 TR 93.666688
141 71 T 1 TR 46.356987
142 71 R 2 TR 154.261807
143 72 T 1 TR 64.971391
144 72 R 2 TR 86.229551
145 73 T 1 TR 124.267496
146 73 R 2 TR 44.075529
147 74 T 1 TR 102.50438
148 74 R 2 TR 65.671553
149 75 T 1 TR 192.921236
150 75 R 2 TR 159.549886
151 76 T 1 TR 139.860682
152 76 R 2 TR 48.284116
153 77 T 1 TR 180.015471
154 77 R 2 TR 37.406489
155 78 T 1 TR 47.504776
156 78 R 2 TR 103.88538
157 79 T 1 TR 152.455655
158 79 R 2 TR 27.601397
159 80 T 1 TR 21.751998
160 80 R 2 TR 142.694036
161 81 T 1 TR 153.242385
162 81 R 2 TR 113.851401
163 82 T 1 TR 144.233457
164 82 R 2 TR 77.758708
165 83 T 1 TR 169.005982
166 83 R 2 TR 259.043321
167 84 T 1 TR 103.898444
168 84 R 2 TR 328.335937
169 85 T 1 TR 91.144717
170 85 R 2 TR 40.945415
171 86 T 1 TR 132.892083
172 86 R 2 TR 48.19294
173 87 T 1 TR 113.169778
174 87 R 2 TR 243.484471
175 88 T 1 TR 190.51489
176 88 R 2 TR 98.386893
177 89 T 1 TR 286.293659
178 89 R 2 TR 81.618075
179 90 T 1 TR 82.835909
180 90 R 2 TR 47.889937
181 91 T 1 TR 131.230182
182 91 R 2 TR 29.492884
183 92 T 1 TR 118.751423
184 92 R 2 TR 83.159735
185 93 T 1 TR 183.36451
186 93 R 2 TR 70.742745
187 94 T 1 TR 210.322872
188 94 R 2 TR 63.895446
189 95 T 1 TR 146.877947
190 95 R 2 TR 123.020424
191 96 T 1 TR 223.835592
192 96 R 2 TR 270.218216
193 97 T 1 TR 146.595607
194 97 R 2 TR 132.657216
195 98 T 1 TR 123.077675
196 98 R 2 TR 176.314701
197 99 T 1 TR 124.872816
198 99 R 2 TR 47.600324
199 100 T 1 TR 286.913104
200 100 R 2 TR 226.279942
201 101 T 1 TR 97.79347
202 101 R 2 TR 210.590012
203 102 T 1 TR 225.007787
204 102 R 2 TR 41.975785
205 103 T 1 TR 127.52834
206 103 R 2 TR 127.140115
207 104 T 1 TR 184.347956
208 104 R 2 TR 63.053496
209 105 T 1 TR 123.124305
210 105 R 2 TR 109.987573
211 106 T 1 TR 48.079555
212 106 R 2 TR 60.455853
213 107 T 1 TR 126.518449
214 107 R 2 TR 91.461536
215 108 T 1 TR 104.863394
216 108 R 2 TR 221.225047
217 109 T 1 TR 118.54898
218 109 R 2 TR 66.237388
219 110 T 1 TR 59.561636
220 110 R 2 TR 78.44783
221 111 T 1 TR 107.402087
222 111 R 2 TR 84.143441
223 112 T 1 TR 198.588871
224 112 R 2 TR 183.319267
225 113 T 1 TR 63.286124
226 113 R 2 TR 83.181234
227 114 T 1 TR 302.006999
228 114 R 2 TR 61.350352
229 115 T 1 TR 100.794072
230 115 R 2 TR 61.806767
231 116 T 1 TR 218.019955
232 116 R 2 TR 105.76597
233 117 T 1 TR 107.20597
234 117 R 2 TR 64.027326
235 118 T 1 TR 138.422019
236 118 R 2 TR 88.968252
237 119 T 1 TR 84.468848
238 119 R 2 TR 185.087987
239 120 T 1 TR 183.323255
240 120 R 2 TR 111.685579
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1566 783 T 2 RT 28.757486
1567 784 R 1 RT 214.141601
1568 784 T 2 RT 65.093178
1569 785 R 1 RT 185.290884
1570 785 T 2 RT 17.746754
1571 786 R 1 RT 95.303229
1572 786 T 2 RT 64.062993
1573 787 R 1 RT 71.35516
1574 787 T 2 RT 58.1451
1575 788 R 1 RT 106.999547
1576 788 T 2 RT 53.479354
1577 789 R 1 RT 130.102053
1578 789 T 2 RT 28.984008
1579 790 R 1 RT 39.510301
1580 790 T 2 RT 43.393102
1581 791 R 1 RT 26.556733
1582 791 T 2 RT 34.466274
1583 792 R 1 RT 91.550772
1584 792 T 2 RT 39.645251
1585 793 R 1 RT 27.172838
1586 793 T 2 RT 72.48696
1587 794 R 1 RT 32.350773
1588 794 T 2 RT 90.19251
1589 795 R 1 RT 137.341852
1590 795 T 2 RT 46.410926
1591 796 R 1 RT 113.183594
1592 796 T 2 RT 114.936548
1593 797 R 1 RT 71.07732
1594 797 T 2 RT 44.250123
1595 798 R 1 RT 137.37908
1596 798 T 2 RT 79.552476
1597 799 R 1 RT 134.991685
1598 799 T 2 RT 74.050127
1599 800 R 1 RT 51.915536
1600 800 T 2 RT 49.197153
1601 801 R 1 RT 194.884737
1602 801 T 2 RT 78.839694
1603 802 R 1 RT 161.925398
1604 802 T 2 RT 61.324184
1605 803 R 1 RT 67.248003
1606 803 T 2 RT 50.408407
1607 804 R 1 RT 48.47597
1608 804 T 2 RT 43.319987
1609 805 R 1 RT 75.046549
1610 805 T 2 RT 22.481832
1611 806 R 1 RT 141.578469
1612 806 T 2 RT 52.41303
1613 807 R 1 RT 125.866909
1614 807 T 2 RT 22.571804
1615 808 R 1 RT 65.392688
1616 808 T 2 RT 61.689452
1617 809 R 1 RT 106.229114
1618 809 T 2 RT 48.569299
1619 810 R 1 RT 115.864583
1620 810 T 2 RT 44.114146
1621 811 R 1 RT 87.508615
1622 811 T 2 RT 47.478279
1623 812 R 1 RT 147.293205
1624 812 T 2 RT 45.264733
1625 813 R 1 RT 45.308443
1626 813 T 2 RT 40.072575
1627 814 R 1 RT 129.902577
1628 814 T 2 RT 39.046468
1629 815 R 1 RT 91.13356
1630 815 T 2 RT 62.021384
1631 816 R 1 RT 163.123391
1632 816 T 2 RT 49.29182
1633 817 R 1 RT 133.987931
1634 817 T 2 RT 28.148875
1635 818 R 1 RT 140.620171
1636 818 T 2 RT 22.668993
1637 819 R 1 RT 128.992661
1638 819 T 2 RT 58.309522
1639 820 R 1 RT 177.664612
1640 820 T 2 RT 35.370008
1641 821 R 1 RT 124.855857
1642 821 T 2 RT 48.282006
1643 822 R 1 RT 143.732161
1644 822 T 2 RT 34.048288
1645 823 R 1 RT 135.869363
1646 823 T 2 RT 37.398536
1647 824 R 1 RT 164.886286
1648 824 T 2 RT 28.562841
1649 825 R 1 RT 160.200176
1650 825 T 2 RT 121.368487
1651 826 R 1 RT 78.962027
1652 826 T 2 RT 116.517509
1653 827 R 1 RT 96.946641
1654 827 T 2 RT 106.24664
1655 828 R 1 RT 116.40963
1656 828 T 2 RT 20.591222
1657 829 R 1 RT 193.047472
1658 829 T 2 RT 23.12487
1659 830 R 1 RT 41.612152
1660 830 T 2 RT 54.650836
1661 831 R 1 RT 224.044058
1662 831 T 2 RT 72.808413
1663 832 R 1 RT 172.056391
1664 832 T 2 RT 78.212415
1665 833 R 1 RT 142.010073
1666 833 T 2 RT 51.355663
1667 834 R 1 RT 108.184885
1668 834 T 2 RT 51.50806
1669 835 R 1 RT 154.133944
1670 835 T 2 RT 66.326649
1671 836 R 1 RT 104.543808
1672 836 T 2 RT 59.448369
1673 837 R 1 RT 105.590966
1674 837 T 2 RT 54.343691
1675 838 R 1 RT 40.083405
1676 838 T 2 RT 38.765192
1677 839 R 1 RT 193.004382
1678 839 T 2 RT 26.398919
1679 840 R 1 RT 251.844451
1680 840 T 2 RT 43.719662
1681 841 R 1 RT 166.592002
1682 841 T 2 RT 67.090375
1683 842 R 1 RT 78.179657
1684 842 T 2 RT 68.169797
1685 843 R 1 RT 94.386623
1686 843 T 2 RT 61.045122
1687 844 R 1 RT 137.49845
1688 844 T 2 RT 21.138422
1689 845 R 1 RT 70.508704
1690 845 T 2 RT 56.983627
1691 846 R 1 RT 146.948694
1692 846 T 2 RT 50.208675
1693 847 R 1 RT 129.880769
1694 847 T 2 RT 24.411917
1695 848 R 1 RT 84.839824
1696 848 T 2 RT 58.728467
1697 849 R 1 RT 78.414479
1698 849 T 2 RT 66.063919
1699 850 R 1 RT 63.310193
1700 850 T 2 RT 29.421003
1701 851 R 1 RT 147.39206
1702 851 T 2 RT 77.104957
1703 852 R 1 RT 135.213234
1704 852 T 2 RT 41.492333
1705 853 R 1 RT 178.520275
1706 853 T 2 RT 30.320321
1707 854 R 1 RT 120.103004
1708 854 T 2 RT 12.772493
1709 855 R 1 RT 171.766957
1710 855 T 2 RT 28.651375
1711 856 R 1 RT 122.601341
1712 856 T 2 RT 33.955296
1713 857 R 1 RT 39.088046
1714 857 T 2 RT 84.922422
1715 858 R 1 RT 180.098018
1716 858 T 2 RT 29.055944
1717 859 R 1 RT 177.656796
1718 859 T 2 RT 111.672803
1719 860 R 1 RT 212.315289
1720 860 T 2 RT 14.825423
1721 861 R 1 RT 146.470639
1722 861 T 2 RT 41.147613
1723 862 R 1 RT 32.179003
1724 862 T 2 RT 20.839854
1725 863 R 1 RT 58.009335
1726 863 T 2 RT 39.228031
1727 864 R 1 RT 74.204151
1728 864 T 2 RT 48.557287
1729 865 R 1 RT 80.050552
1730 865 T 2 RT 33.460836
1731 866 R 1 RT 159.112634
1732 866 T 2 RT 76.471496
1733 867 R 1 RT 155.942708
1734 867 T 2 RT 42.016347
1735 868 R 1 RT 115.641876
1736 868 T 2 RT 62.494289
1737 869 R 1 RT 88.308478
1738 869 T 2 RT 72.45808
1739 870 R 1 RT 81.606943
1740 870 T 2 RT 72.493888
1741 871 R 1 RT 51.230993
1742 871 T 2 RT 27.68642
1743 872 R 1 RT 43.204421
1744 872 T 2 RT 38.454195
1745 873 R 1 RT 54.805595
1746 873 T 2 RT 63.526333
1747 874 R 1 RT 49.186541
1748 874 T 2 RT 79.028585
1749 875 R 1 RT 195.887
1750 875 T 2 RT 111.555697
1751 876 R 1 RT 217.084291
1752 876 T 2 RT 31.002708
1753 877 R 1 RT 104.834529
1754 877 T 2 RT 110.392978
1755 878 R 1 RT 50.369434
1756 878 T 2 RT 68.113822
1757 879 R 1 RT 74.005703
1758 879 T 2 RT 44.197872
1759 880 R 1 RT 78.406454
1760 880 T 2 RT 30.939164
1761 881 R 1 RT 112.288434
1762 881 T 2 RT 83.590771
1763 882 R 1 RT 39.147747
1764 882 T 2 RT 101.184682
1765 883 R 1 RT 63.869062
1766 883 T 2 RT 75.891583
1767 884 R 1 RT 59.028159
1768 884 T 2 RT 28.872403
1769 885 R 1 RT 67.364535
1770 885 T 2 RT 40.684269
1771 886 R 1 RT 70.096729
1772 886 T 2 RT 75.063432
1773 887 R 1 RT 160.957586
1774 887 T 2 RT 21.168826
1775 888 R 1 RT 170.776253
1776 888 T 2 RT 18.349436
1777 889 R 1 RT 87.661461
1778 889 T 2 RT 59.017537
1779 890 R 1 RT 47.45405
1780 890 T 2 RT 23.323079
1781 891 R 1 RT 50.287122
1782 891 T 2 RT 44.155513
1783 892 R 1 RT 106.024431
1784 892 T 2 RT 43.317674
1785 893 R 1 RT 61.846403
1786 893 T 2 RT 77.031274
1787 894 R 1 RT 67.206834
1788 894 T 2 RT 28.240248
1789 895 R 1 RT 104.041673
1790 895 T 2 RT 29.096845
1791 896 R 1 RT 145.427953
1792 896 T 2 RT 81.652023
1793 897 R 1 RT 89.128766
1794 897 T 2 RT 34.534524
1795 898 R 1 RT 41.53923
1796 898 T 2 RT 23.17659
1797 899 R 1 RT 124.208992
1798 899 T 2 RT 30.562138
1799 900 R 1 RT 121.683495
1800 900 T 2 RT 39.502194
1801 901 R 1 RT 79.681988
1802 901 T 2 RT 68.139026
1803 902 R 1 RT 69.739445
1804 902 T 2 RT 47.077311
1805 903 R 1 RT 85.542148
1806 903 T 2 RT 36.323054
1807 904 R 1 RT 158.248564
1808 904 T 2 RT 62.808395
1809 905 R 1 RT 118.674608
1810 905 T 2 RT 54.513566
1811 906 R 1 RT 41.946036
1812 906 T 2 RT 73.529917
1813 907 R 1 RT 188.276205
1814 907 T 2 RT 49.390198
1815 908 R 1 RT 121.51933
1816 908 T 2 RT 46.659987
1817 909 R 1 RT 128.607209
1818 909 T 2 RT 218.305927
1819 910 R 1 RT 100.334661
1820 910 T 2 RT 74.662788
1821 911 R 1 RT 89.827414
1822 911 T 2 RT 82.017425
1823 912 R 1 RT 126.791449
1824 912 T 2 RT 136.757272
1825 913 R 1 RT 65.833856
1826 913 T 2 RT 27.090757
1827 914 R 1 RT 94.143016
1828 914 T 2 RT 94.097509
1829 915 R 1 RT 54.633113
1830 915 T 2 RT 19.377575
1831 916 R 1 RT 187.461582
1832 916 T 2 RT 47.801583
1833 917 R 1 RT 104.439106
1834 917 T 2 RT 42.849634
1835 918 R 1 RT 132.983453
1836 918 T 2 RT 55.076696
1837 919 R 1 RT 182.157387
1838 919 T 2 RT 31.157375
1839 920 R 1 RT 76.119124
1840 920 T 2 RT 70.659956
1841 921 R 1 RT 102.928781
1842 921 T 2 RT 60.534292
1843 922 R 1 RT 53.156721
1844 922 T 2 RT 36.581714
1845 923 R 1 RT 67.522173
1846 923 T 2 RT 31.650077
1847 924 R 1 RT 131.040951
1848 924 T 2 RT 43.431226
1849 925 R 1 RT 47.600722
1850 925 T 2 RT 70.390813
1851 926 R 1 RT 40.811684
1852 926 T 2 RT 23.685714
1853 927 R 1 RT 76.784577
1854 927 T 2 RT 90.06403
1855 928 R 1 RT 180.818772
1856 928 T 2 RT 49.379303
1857 929 R 1 RT 143.177846
1858 929 T 2 RT 81.677379
1859 930 R 1 RT 96.574839
1860 930 T 2 RT 146.43942
1861 931 R 1 RT 79.460967
1862 931 T 2 RT 22.93561
1863 932 R 1 RT 153.829699
1864 932 T 2 RT 37.114269
1865 933 R 1 RT 146.218318
1866 933 T 2 RT 82.99556
1867 934 R 1 RT 75.829605
1868 934 T 2 RT 37.195603
1869 935 R 1 RT 71.753416
1870 935 T 2 RT 28.128414
1871 936 R 1 RT 182.777618
1872 936 T 2 RT 67.956769
1873 937 R 1 RT 106.045262
1874 937 T 2 RT 32.082671
1875 938 R 1 RT 320.144744
1876 938 T 2 RT 55.658141
1877 939 R 1 RT 71.722902
1878 939 T 2 RT 106.388061
1879 940 R 1 RT 90.04291
1880 940 T 2 RT 31.649235
1881 941 R 1 RT 187.197933
1882 941 T 2 RT 30.860369
1883 942 R 1 RT 61.130344
1884 942 T 2 RT 83.724571
1885 943 R 1 RT 123.698058
1886 943 T 2 RT 100.709964
1887 944 R 1 RT 69.096319
1888 944 T 2 RT 39.471993
1889 945 R 1 RT 249.693588
1890 945 T 2 RT 25.610807
1891 946 R 1 RT 90.053031
1892 946 T 2 RT 57.186015
1893 947 R 1 RT 161.222265
1894 947 T 2 RT 77.590901
1895 948 R 1 RT 110.644793
1896 948 T 2 RT 46.424147
1897 949 R 1 RT 101.62879
1898 949 T 2 RT 117.992312
1899 950 R 1 RT 42.59
1900 950 T 2 RT 197.832993
1901 951 R 1 RT 86.392822
1902 951 T 2 RT 55.721804
1903 952 R 1 RT 93.537947
1904 952 T 2 RT 36.713212
1905 953 R 1 RT 103.145225
1906 953 T 2 RT 68.675397
1907 954 R 1 RT 108.801391
1908 954 T 2 RT 21.015539
1909 955 R 1 RT 253.112157
1910 955 T 2 RT 63.819078
1911 956 R 1 RT 34.723305
1912 956 T 2 RT 23.174148
1913 957 R 1 RT 44.195532
1914 957 T 2 RT 90.627557
1915 958 R 1 RT 172.53421
1916 958 T 2 RT 21.767711
1917 959 R 1 RT 104.418557
1918 959 T 2 RT 132.784817
1919 960 R 1 RT 148.995496
1920 960 T 2 RT 72.25459
1921 961 R 1 RT 139.235947
1922 961 T 2 RT 21.048731
1923 962 R 1 RT 68.443055
1924 962 T 2 RT 107.741872
1925 963 R 1 RT 165.729851
1926 963 T 2 RT 62.650965
1927 964 R 1 RT 247.197188
1928 964 T 2 RT 37.688279
1929 965 R 1 RT 85.98977
1930 965 T 2 RT 99.35077
1931 966 R 1 RT 69.418449
1932 966 T 2 RT 17.996155
1933 967 R 1 RT 76.98232
1934 967 T 2 RT 27.032075
1935 968 R 1 RT 85.289183
1936 968 T 2 RT 45.368731
1937 969 R 1 RT 59.875173
1938 969 T 2 RT 25.37233
1939 970 R 1 RT 100.365754
1940 970 T 2 RT 54.21029
1941 971 R 1 RT 81.283211
1942 971 T 2 RT 39.810166
1943 972 R 1 RT 79.873567
1944 972 T 2 RT 57.122919
1945 973 R 1 RT 121.08553
1946 973 T 2 RT 40.406514
1947 974 R 1 RT 44.045074
1948 974 T 2 RT 33.226413
1949 975 R 1 RT 114.673124
1950 975 T 2 RT 17.796087
1951 976 R 1 RT 80.124046
1952 976 T 2 RT 37.736682
1953 977 R 1 RT 60.22591
1954 977 T 2 RT 102.943701
1955 978 R 1 RT 36.598551
1956 978 T 2 RT 86.611485
1957 979 R 1 RT 120.153601
1958 979 T 2 RT 80.772765
1959 980 R 1 RT 112.020149
1960 980 T 2 RT 17.684774
1961 981 R 1 RT 35.650606
1962 981 T 2 RT 74.788404
1963 982 R 1 RT 208.015452
1964 982 T 2 RT 24.713801
1965 983 R 1 RT 52.969681
1966 983 T 2 RT 54.812334
1967 984 R 1 RT 158.812733
1968 984 T 2 RT 29.611692
1969 985 R 1 RT 113.229607
1970 985 T 2 RT 34.999537
1971 986 R 1 RT 62.151407
1972 986 T 2 RT 108.580431
1973 987 R 1 RT 218.832947
1974 987 T 2 RT 165.297431
1975 988 R 1 RT 132.168555
1976 988 T 2 RT 66.855143
1977 989 R 1 RT 88.202967
1978 989 T 2 RT 129.654667
1979 990 R 1 RT 209.838281
1980 990 T 2 RT 61.007877
1981 991 R 1 RT 173.227324
1982 991 T 2 RT 97.753317
1983 992 R 1 RT 133.652768
1984 992 T 2 RT 40.359907
1985 993 R 1 RT 185.817376
1986 993 T 2 RT 24.437546
1987 994 R 1 RT 244.451413
1988 994 T 2 RT 33.922265
1989 995 R 1 RT 90.175789
1990 995 T 2 RT 47.07753
1991 996 R 1 RT 128.803679
1992 996 T 2 RT 102.542773
1993 997 R 1 RT 85.670869
1994 997 T 2 RT 45.720415
1995 998 R 1 RT 286.780345
1996 998 T 2 RT 73.954228
1997 999 R 1 RT 63.111898
1998 999 T 2 RT 13.300927
1999 1000 R 1 RT 55.80308
2000 1000 T 2 RT 50.057746
;
RUN;

ods graphics off;
PROC GLM data=pkdata;
CLASS Period Sequence Formulation Subject;
MODEL logCMAX = Sequence Subject(Sequence) Period Formulation/CLPARM ALPHA=0.1;
RANDOM Subject(Sequence) /TEST;
LSMEANS Formulation / PDIFF=control("R") CL ALPHA=0.1;
ESTIMATE 'T vs R' Formulation -1 1;
ods output LSMeanDiffCL=LSMeanDiffCL;
RUN;

PROC APPEND base=result data=work.lsmeandiffcl;
RUN;

proc datasets lib=work nolist;
delete lsmeandiffcl;
run;

DATA result (drop=i j Dependent Difference _Formulation LowerCL UpperCL);
set result;
LowerCI = exp(LowerCL)*100;
Diff = exp(Difference)*100;
UpperCI = exp(UpperCL)*100;
RUN;

[свернуть]

Datasets H

proc datasets lib=work nolist;
delete result;
run;

DATA pkdata;
infile datalines dlm=" " truncover;
input ObsN $ Subject $ Formulation $ Period $ Sequence $ Cmax;
logCMAX=log(Cmax);
datalines;
1 1 T 1 TR 168.406971
2 1 R 2 TR 210.919302
3 2 T 1 TR 131.030557
4 2 R 2 TR 67.431371
5 3 T 1 TR 151.736588
6 3 R 2 TR 85.12962
7 4 T 1 TR 375.575338
8 4 R 2 TR 147.501644
9 5 T 1 TR 50.022999
10 5 R 2 TR 20.010703
11 6 T 1 TR 185.146675
12 6 R 2 TR 35.799928
13 7 T 1 TR 587.468348
14 7 R 2 TR 37.402211
15 8 T 1 TR 144.208919
16 8 R 2 TR 101.714056
17 9 T 1 TR 136.093807
18 9 R 2 TR 38.71825
19 10 T 1 TR 152.131435
20 10 R 2 TR 62.823091
21 11 T 1 TR 108.381288
22 11 R 2 TR 109.279346
23 12 T 1 TR 394.97575
24 12 R 2 TR 48.489544
25 13 T 1 TR 231.583991
26 13 R 2 TR 85.289332
27 14 T 1 TR 381.700475
28 14 R 2 TR 137.728689
29 15 T 1 TR 253.503735
30 15 R 2 TR 471.986382
31 16 T 1 TR 191.845477
32 16 R 2 TR 134.573858
33 17 T 1 TR 104.103038
34 17 R 2 TR 157.743293
35 18 T 1 TR 69.353727
36 18 R 2 TR 56.295695
37 19 T 1 TR 130.15899
38 19 R 2 TR 55.903509
39 20 T 1 TR 72.949174
40 20 R 2 TR 151.363897
41 21 T 1 TR 58.094988
42 21 R 2 TR 112.780416
43 22 T 1 TR 264.356947
44 22 R 2 TR 44.187525
45 23 T 1 TR 179.653272
46 23 R 2 TR 164.924611
47 24 T 1 TR 86224452
48 24 R 2 TR 135.473163
49 25 T 1 TR 84.136188
50 25 R 2 TR 81.371995
51 26 T 1 TR 285.259889
52 26 R 2 TR 39.442794
53 27 T 1 TR 62.94776
54 27 R 2 TR 27.681993
55 28 T 1 TR 235.506388
56 28 R 2 TR 77.015332
57 29 T 1 TR 390.663369
58 29 R 2 TR 88.328537
59 30 T 1 TR 120.493118
60 30 R 2 TR 173.324111
61 31 T 1 TR 111.596694
62 31 R 2 TR 78.931687
63 32 T 1 TR 158.648779
64 32 R 2 TR 151.862284
65 33 T 1 TR 329.994846
66 33 R 2 TR 50.841212
67 34 T 1 TR 350.636138
68 34 R 2 TR 67.259865
69 35 T 1 TR 332.622841
70 35 R 2 TR 97.307566
71 36 T 1 TR 243.856611
72 36 R 2 TR 47.113278
73 37 T 1 TR 153.605199
74 37 R 2 TR 59.27053
75 38 T 1 TR 147.857188
76 38 R 2 TR 132.689376
77 39 T 1 TR 103.785184
78 39 R 2 TR 114.532132
79 40 T 1 TR 133.067055
80 40 R 2 TR 51.618138
81 41 T 1 TR 161.160942
82 41 R 2 TR 43.599003
83 42 T 1 TR 237.253839
84 42 R 2 TR 122.033155
85 43 T 1 TR 161.275489
86 43 R 2 TR 39.952842
87 44 T 1 TR 67.579371
88 44 R 2 TR 40.759446
89 45 T 1 TR 242.157358
90 45 R 2 TR 181.071583
91 46 T 1 TR 79.226592
92 46 R 2 TR 110.111699
93 47 T 1 TR 137.963141
94 47 R 2 TR 68.21396
95 48 T 1 TR 37.985895
96 48 R 2 TR 44.611124
97 49 T 1 TR 116.333397
98 49 R 2 TR 49.860836
99 50 T 1 TR 179.71508
100 50 R 2 TR 54.845762
101 51 T 1 TR 208527253
102 51 R 2 TR 77.6953
103 52 T 1 TR 197.790404
104 52 R 2 TR 387.71256
105 53 T 1 TR 106.746212
106 53 R 2 TR 64.236185
107 54 T 1 TR 304.717464
108 54 R 2 TR 64.451299
109 55 T 1 TR 93.296734
110 55 R 2 TR 68.059482
111 56 T 1 TR 80.841629
112 56 R 2 TR 273.69493
113 57 T 1 TR 107.647821
114 57 R 2 TR 110.74907
115 58 T 1 TR 59.997872
116 58 R 2 TR 116.531007
117 59 T 1 TR 91.760423
118 59 R 2 TR 207.829153
119 60 T 1 TR 58.681863
120 60 R 2 TR 128.265635
121 61 T 1 TR 91.900425
122 61 R 2 TR 85.526564
123 62 T 1 TR 170.110252
124 62 R 2 TR 36.666705
125 63 T 1 TR 113.270703
126 63 R 2 TR 134.149143
127 64 T 1 TR 194.339872
128 64 R 2 TR 147.257305
129 65 T 1 TR 403.204529
130 65 R 2 TR 68.466399
131 66 T 1 TR 121.761246
132 66 R 2 TR 50.135768
133 67 T 1 TR 98.679855
134 67 R 2 TR 156.526051
135 68 T 1 TR 209.223928
136 68 R 2 TR 50.994698
137 69 T 1 TR 144.705439
138 69 R 2 TR 61.959952
139 70 T 1 TR 168406971
140 70 R 2 TR 210919302
141 71 T 1 TR 131030557
142 71 R 2 TR 67431371
143 72 T 1 TR 151736588
144 72 R 2 TR 85129620
145 73 T 1 TR 375575338
146 73 R 2 TR 147501644
147 74 T 1 TR 50022999
148 74 R 2 TR 20010703
149 75 T 1 TR 185146675
150 75 R 2 TR 35799928
151 76 T 1 TR 587468348
152 76 R 2 TR 37402211
153 77 T 1 TR 144208919
154 77 R 2 TR 101714056
155 78 T 1 TR 136093807
156 78 R 2 TR 38718250
157 79 T 1 TR 152131435
158 79 R 2 TR 62823091
159 80 T 1 TR 108381288
160 80 R 2 TR 109279346
161 81 T 1 TR 394975750
162 81 R 2 TR 48489544
163 82 T 1 TR 231583991
164 82 R 2 TR 85289332
165 83 T 1 TR 381700475
166 83 R 2 TR 137728689
167 84 T 1 TR 253503735
168 84 R 2 TR 471986382
169 85 T 1 TR 191845477
170 85 R 2 TR 134573858
171 86 T 1 TR 104103038
172 86 R 2 TR 157743293
173 87 T 1 TR 69353727
174 87 R 2 TR 56295695
175 88 T 1 TR 130158990
176 88 R 2 TR 55903509
177 89 T 1 TR 72949174
178 89 R 2 TR 151363897
179 90 T 1 TR 58094988
180 90 R 2 TR 112780416
181 91 T 1 TR 131.230182
182 91 R 2 TR 29.492884
183 92 T 1 TR 118.751423
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884 725 T 2 RT 10.363764
885 726 R 1 RT 132.777817
886 726 T 2 RT 62.116482
887 727 R 1 RT 119.555561
888 727 T 2 RT 29.538648
889 728 R 1 RT 59.380688
890 728 T 2 RT 92.051686
891 729 R 1 RT 143.833543
892 729 T 2 RT 59.504076
893 730 R 1 RT 62.010224
894 730 T 2 RT 33.775839
895 731 R 1 RT 44.519571
896 731 T 2 RT 62.014367
897 732 R 1 RT 100.124222
898 732 T 2 RT 27.100176
899 733 R 1 RT 45.899715
900 733 T 2 RT 36.116313
901 734 R 1 RT 201.606711
902 734 T 2 RT 22.338796
903 735 R 1 RT 103.579455
904 735 T 2 RT 65.674975
905 736 R 1 RT 70.174175
906 736 T 2 RT 19.955042
907 737 R 1 RT 100.870716
908 737 T 2 RT 33.193658
909 738 R 1 RT 95.207021
910 738 T 2 RT 70.659333
911 739 R 1 RT 107.679115
912 739 T 2 RT 63.06282
913 740 R 1 RT 48.024315
914 740 T 2 RT 24.861242
915 741 R 1 RT 56.849742
916 741 T 2 RT 33.840535
917 742 R 1 RT 168.795221
918 742 T 2 RT 64.290978
919 743 R 1 RT 69.394826
920 743 T 2 RT 21.518877
921 744 R 1 RT 146.728242
922 744 T 2 RT 18.40682
923 745 R 1 RT 146.161602
924 745 T 2 RT 9.244367
925 746 R 1 RT 164.592141
926 746 T 2 RT 53.894448
927 747 R 1 RT 89.605563
928 747 T 2 RT 36.24532
929 748 R 1 RT 74.023563
930 748 T 2 RT 26.668284
931 749 R 1 RT 84.154735
932 749 T 2 RT 55.030694
933 750 R 1 RT 112.470894
934 750 T 2 RT 103.318191
935 751 R 1 RT 167.806121
936 751 T 2 RT 43.552288
937 752 R 1 RT 37.1225
938 752 T 2 RT 69.13395
939 753 R 1 RT 166.53274
940 753 T 2 RT 33.370163
941 754 R 1 RT 197.655968
942 754 T 2 RT 100.571211
943 755 R 1 RT 92.052815
944 755 T 2 RT 46.402303
945 756 R 1 RT 193.50814
946 756 T 2 RT 123.61536
947 757 R 1 RT 70.499354
948 757 T 2 RT 84.622621
949 758 R 1 RT 114.065352
950 758 T 2 RT 22.791684
951 759 R 1 RT 38.053298
952 759 T 2 RT 74.802469
953 760 R 1 RT 76.064746
954 760 T 2 RT 28.047096
955 761 R 1 RT 133.68108
956 761 T 2 RT 26.039984
957 762 R 1 RT 174.359859
958 762 T 2 RT 86.845153
959 763 R 1 RT 69.537569
960 763 T 2 RT 37.173252
961 764 R 1 RT 82.842188
962 764 T 2 RT 122.994372
963 765 R 1 RT 220.659124
964 765 T 2 RT 33.371914
965 766 R 1 RT 52.999629
966 766 T 2 RT 69.780826
967 767 R 1 RT 99.486694
968 767 T 2 RT 48.915489
969 768 R 1 RT 204.266458
970 768 T 2 RT 33.984306
971 769 R 1 RT 124.760648
972 769 T 2 RT 40.857466
973 770 R 1 RT 120.385003
974 770 T 2 RT 43.378046
975 771 R 1 RT 120.904075
976 771 T 2 RT 39.392856
977 772 R 1 RT 79.205939
978 772 T 2 RT 55.752976
979 773 R 1 RT 127.492748
980 773 T 2 RT 97.520995
981 774 R 1 RT 102.746828
982 774 T 2 RT 69.072422
983 775 R 1 RT 67.940283
984 775 T 2 RT 53.301612
985 776 R 1 RT 241.469596
986 776 T 2 RT 27.204767
987 777 R 1 RT 125.460046
988 777 T 2 RT 71.331344
989 778 R 1 RT 58.683202
990 778 T 2 RT 61.893909
991 779 R 1 RT 276.991959
992 779 T 2 RT 52.426114
993 780 R 1 RT 29.212122
994 780 T 2 RT 48.409961
995 781 R 1 RT 44.196491
996 781 T 2 RT 56.43651
997 782 R 1 RT 87.710408
998 782 T 2 RT 19.98237
999 783 R 1 RT 71.231453
1000 783 T 2 RT 28.757486
1001 784 R 1 RT 214.141601
1002 784 T 2 RT 65.093178
1003 785 R 1 RT 185.290884
1004 785 T 2 RT 17.746754
1005 786 R 1 RT 95.303229
1006 786 T 2 RT 64.062993
1007 787 R 1 RT 71.35516
1008 787 T 2 RT 58.1451
1009 788 R 1 RT 106.999547
1010 788 T 2 RT 53.479354
1011 789 R 1 RT 130.102053
1012 789 T 2 RT 28.984008
1013 790 R 1 RT 39.510301
1014 790 T 2 RT 43.393102
1015 791 R 1 RT 26.556733
1016 791 T 2 RT 34.466274
1017 792 R 1 RT 91.550772
1018 792 T 2 RT 39.645251
1019 793 R 1 RT 27.172838
1020 793 T 2 RT 72.48696
1021 794 R 1 RT 32.350773
1022 794 T 2 RT 90.19251
1023 795 R 1 RT 137.341852
1024 795 T 2 RT 46.410926
1025 796 R 1 RT 113.183594
1026 796 T 2 RT 114.936548
1027 797 R 1 RT 71.07732
1028 797 T 2 RT 44.250123
1029 798 R 1 RT 137.37908
1030 798 T 2 RT 79.552476
1031 799 R 1 RT 134.991685
1032 799 T 2 RT 74.050127
1033 800 R 1 RT 51.915536
1034 800 T 2 RT 49.197153
1035 801 R 1 RT 194.884737
1036 801 T 2 RT 78.839694
1037 802 R 1 RT 161.925398
1038 802 T 2 RT 61.324184
1039 803 R 1 RT 67.248003
1040 803 T 2 RT 50.408407
1041 804 R 1 RT 48.47597
1042 804 T 2 RT 43.319987
1043 805 R 1 RT 75.046549
1044 805 T 2 RT 22.481832
1045 806 R 1 RT 141.578469
1046 806 T 2 RT 52.41303
1047 807 R 1 RT 125.866909
1048 807 T 2 RT 22.571804
1049 808 R 1 RT 65.392688
1050 808 T 2 RT 61.689452
1051 809 R 1 RT 106.229114
1052 809 T 2 RT 48.569299
1053 810 R 1 RT 115.864583
1054 810 T 2 RT 44.114146
1055 811 R 1 RT 87.508615
1056 811 T 2 RT 47.478279
1057 812 R 1 RT 147.293205
1058 812 T 2 RT 45.264733
1059 813 R 1 RT 45.308443
1060 813 T 2 RT 40.072575
1061 814 R 1 RT 129.902577
1062 814 T 2 RT 39.046468
1063 815 R 1 RT 91.13356
1064 815 T 2 RT 62.021384
1065 816 R 1 RT 163.123391
1066 816 T 2 RT 49.29182
1067 817 R 1 RT 133.987931
1068 817 T 2 RT 28.148875
1069 818 R 1 RT 140.620171
1070 818 T 2 RT 22.668993
1071 819 R 1 RT 128.992661
1072 819 T 2 RT 58.309522
1073 820 R 1 RT 177.664612
1074 820 T 2 RT 35.370008
1075 821 R 1 RT 124.855857
1076 821 T 2 RT 48.282006
1077 822 R 1 RT 143.732161
1078 822 T 2 RT 34.048288
1079 823 R 1 RT 135.869363
1080 823 T 2 RT 37.398536
1081 824 R 1 RT 164.886286
1082 824 T 2 RT 28.562841
1083 825 R 1 RT 160.200176
1084 825 T 2 RT 121.368487
1085 826 R 1 RT 78.962027
1086 826 T 2 RT 116.517509
1087 827 R 1 RT 96.946641
1088 827 T 2 RT 106.24664
1089 828 R 1 RT 116.40963
1090 828 T 2 RT 20.591222
1091 829 R 1 RT 193.047472
1092 829 T 2 RT 23.12487
1093 830 R 1 RT 41.612152
1094 830 T 2 RT 54.650836
1095 831 R 1 RT 224.044058
1096 831 T 2 RT 72.808413
1097 832 R 1 RT 172.056391
1098 832 T 2 RT 78.212415
1099 833 R 1 RT 142.010073
1100 833 T 2 RT 51.355663
1101 834 R 1 RT 108.184885
1102 834 T 2 RT 51.50806
1103 835 R 1 RT 154.133944
1104 835 T 2 RT 66.326649
1105 836 R 1 RT 104.543808
1106 836 T 2 RT 59.448369
1107 837 R 1 RT 105.590966
1108 837 T 2 RT 54.343691
1109 838 R 1 RT 40.083405
1110 838 T 2 RT 38.765192
1111 839 R 1 RT 193.004382
1112 839 T 2 RT 26.398919
1113 840 R 1 RT 251.844451
1114 840 T 2 RT 43.719662
1115 841 R 1 RT 166.592002
1116 841 T 2 RT 67.090375
1117 842 R 1 RT 78.179657
1118 842 T 2 RT 68.169797
1119 843 R 1 RT 94.386623
1120 843 T 2 RT 61.045122
1121 844 R 1 RT 137.49845
1122 844 T 2 RT 21.138422
1123 845 R 1 RT 70.508704
1124 845 T 2 RT 56.983627
1125 846 R 1 RT 146.948694
1126 846 T 2 RT 50.208675
1127 847 R 1 RT 129.880769
1128 847 T 2 RT 24.411917
1129 848 R 1 RT 84.839824
1130 848 T 2 RT 58.728467
1131 849 R 1 RT 78.414479
1132 849 T 2 RT 66.063919
1133 850 R 1 RT 63.310193
1134 850 T 2 RT 29.421003
1135 851 R 1 RT 147.39206
1136 851 T 2 RT 77.104957
1137 852 R 1 RT 135.213234
1138 852 T 2 RT 41.492333
1139 853 R 1 RT 178.520275
1140 853 T 2 RT 30.320321
1141 854 R 1 RT 120.103004
1142 854 T 2 RT 12.772493
1143 855 R 1 RT 171.766957
1144 855 T 2 RT 28.651375
1145 856 R 1 RT 122.601341
1146 856 T 2 RT 33.955296
1147 857 R 1 RT 39.088046
1148 857 T 2 RT 84.922422
1149 858 R 1 RT 180.098018
1150 858 T 2 RT 29.055944
1151 859 R 1 RT 177.656796
1152 859 T 2 RT 111.672803
1153 860 R 1 RT 212.315289
1154 860 T 2 RT 14.825423
1155 861 R 1 RT 146.470639
1156 861 T 2 RT 41.147613
1157 862 R 1 RT 32.179003
1158 862 T 2 RT 20.839854
1159 863 R 1 RT 58.009335
1160 863 T 2 RT 39.228031
1161 864 R 1 RT 74.204151
1162 864 T 2 RT 48.557287
1163 865 R 1 RT 80.050552
1164 865 T 2 RT 33.460836
1165 866 R 1 RT 159.112634
1166 866 T 2 RT 76.471496
1167 867 R 1 RT 155.942708
1168 867 T 2 RT 42.016347
1169 868 R 1 RT 115.641876
1170 868 T 2 RT 62.494289
1171 869 R 1 RT 88.308478
1172 869 T 2 RT 72.45808
1173 870 R 1 RT 81.606943
1174 870 T 2 RT 72.493888
1175 871 R 1 RT 51230993
1176 871 T 2 RT 27.68642
1177 872 R 1 RT 43.204421
1178 872 T 2 RT 38.454195
1179 873 R 1 RT 54.805595
1180 873 T 2 RT 63.526333
1181 874 R 1 RT 49.186541
1182 874 T 2 RT 79.028585
1183 875 R 1 RT 195.887
1184 875 T 2 RT 111.555697
1185 876 R 1 RT 217.084291
1186 876 T 2 RT 31.002708
1187 877 R 1 RT 104.834529
1188 877 T 2 RT 110.392978
1189 878 R 1 RT 50.369434
1190 878 T 2 RT 68.113822
1191 879 R 1 RT 74.005703
1192 879 T 2 RT 44.197872
1193 880 R 1 RT 78.406454
1194 880 T 2 RT 30.939164
1195 881 R 1 RT 112.288434
1196 881 T 2 RT 83.590771
1197 882 R 1 RT 39.147747
1198 882 T 2 RT 101.184682
1199 883 R 1 RT 63.869062
1200 883 T 2 RT 75.891583
1201 884 R 1 RT 59.028159
1202 884 T 2 RT 28.872403
1203 885 R 1 RT 67.364535
1204 885 T 2 RT 40.684269
1205 886 R 1 RT 70.096729
1206 886 T 2 RT 75.063432
1207 887 R 1 RT 160.957586
1208 887 T 2 RT 21.168826
1209 888 R 1 RT 170.776253
1210 888 T 2 RT 18.349436
1211 889 R 1 RT 87.661461
1212 889 T 2 RT 59.017537
1213 890 R 1 RT 47.45405
1214 890 T 2 RT 23.323079
1215 891 R 1 RT 50.287122
1216 891 T 2 RT 44.155513
1217 892 R 1 RT 106.024431
1218 892 T 2 RT 43.317674
1219 893 R 1 RT 61.846403
1220 893 T 2 RT 77.031274
1221 894 R 1 RT 67.206834
1222 894 T 2 RT 28.240248
1223 895 R 1 RT 104.041673
1224 895 T 2 RT 29.096845
1225 896 R 1 RT 145.427953
1226 896 T 2 RT 81.652023
1227 897 R 1 RT 89.128766
1228 897 T 2 RT 34.534524
1229 898 R 1 RT 41.53923
1230 898 T 2 RT 23.17659
1231 899 R 1 RT 124.208992
1232 899 T 2 RT 30.562138
1233 900 R 1 RT 121.683495
1234 900 T 2 RT 39.502194
1235 901 R 1 RT 79.681988
1236 901 T 2 RT 68.139026
1237 902 R 1 RT 69.739445
1238 902 T 2 RT 47.077311
1239 903 R 1 RT 85.542148
1240 903 T 2 RT 36.323054
1241 904 R 1 RT 158.248564
1242 904 T 2 RT 62.808395
1243 905 R 1 RT 118.674608
1244 905 T 2 RT 54.513566
1245 906 R 1 RT 41.946036
1246 906 T 2 RT 73.529917
1247 907 R 1 RT 188.276205
1248 907 T 2 RT 49.390198
1249 908 R 1 RT 121.51933
1250 908 T 2 RT 46.659987
1251 909 R 1 RT 128.607209
1252 909 T 2 RT 218.305927
1253 910 R 1 RT 100.334661
1254 910 T 2 RT 74.662788
1255 911 R 1 RT 89.827414
1256 911 T 2 RT 82.017425
1257 912 R 1 RT 126.791449
1258 912 T 2 RT 136.757272
1259 913 R 1 RT 65.833856
1260 913 T 2 RT 27.090757
1261 914 R 1 RT 94.143016
1262 914 T 2 RT 94.097509
1263 915 R 1 RT 54.633113
1264 915 T 2 RT 19.377575
1265 916 R 1 RT 187.461582
1266 916 T 2 RT 47.801583
1267 917 R 1 RT 104.439106
1268 917 T 2 RT 42.849634
1269 918 R 1 RT 132.983453
1270 918 T 2 RT 55.076696
1271 919 R 1 RT 182.157387
1272 919 T 2 RT 31.157375
1273 920 R 1 RT 76.119124
1274 920 T 2 RT 70.659956
1275 921 R 1 RT 102.928781
1276 921 T 2 RT 60.534292
1277 922 R 1 RT 53.156721
1278 922 T 2 RT 36.581714
1279 923 R 1 RT 67.522173
1280 923 T 2 RT 31.650077
1281 924 R 1 RT 131.040951
1282 924 T 2 RT 43.431226
1283 925 R 1 RT 47.600722
1284 925 T 2 RT 70.390813
1285 926 R 1 RT 40.811684
1286 926 T 2 RT 23.685714
1287 927 R 1 RT 76.784577
1288 927 T 2 RT 90.06403
1289 928 R 1 RT 180.818772
1290 928 T 2 RT 49.379303
1291 929 R 1 RT 143.177846
1292 929 T 2 RT 81.677379
1293 930 R 1 RT 96.574839
1294 930 T 2 RT 146.43942
1295 931 R 1 RT 79.460967
1296 931 T 2 RT 22.93561
1297 932 R 1 RT 153.829699
1298 932 T 2 RT 37.114269
1299 933 R 1 RT 146.218318
1300 933 T 2 RT 82.99556
1301 934 R 1 RT 75.829605
1302 934 T 2 RT 37.195603
1303 935 R 1 RT 71.753416
1304 935 T 2 RT 28.128414
1305 936 R 1 RT 182.777618
1306 936 T 2 RT 67.956769
1307 937 R 1 RT 106.045262
1308 937 T 2 RT 32.082671
1309 938 R 1 RT 320.144744
1310 938 T 2 RT 55.658141
1311 939 R 1 RT 71.722902
1312 939 T 2 RT 106.388061
1313 940 R 1 RT 90.04291
1314 940 T 2 RT 31.649235
1315 941 R 1 RT 187.197933
1316 941 T 2 RT 30.860369
1317 942 R 1 RT 61.130344
1318 942 T 2 RT 83.724571
1319 943 R 1 RT 123.698058
1320 943 T 2 RT 100.709964
1321 944 R 1 RT 69.096319
1322 944 T 2 RT 39.471993
1323 945 R 1 RT 249.693588
1324 945 T 2 RT 25.610807
1325 946 R 1 RT 90.053031
1326 946 T 2 RT 57.186015
1327 947 R 1 RT 161.222265
1328 947 T 2 RT 77.590901
1329 948 R 1 RT 110.644793
1330 948 T 2 RT 46.424147
1331 949 R 1 RT 101.62879
1332 949 T 2 RT 117.992312
1333 950 R 1 RT 42.59
1334 950 T 2 RT 197.832993
1335 951 R 1 RT 86.392822
1336 951 T 2 RT 55.721804
1337 952 R 1 RT 93.537947
1338 952 T 2 RT 36.713212
1339 953 R 1 RT 103.145225
1340 953 T 2 RT 68.675397
1341 954 R 1 RT 108.801391
1342 954 T 2 RT 21.015539
1343 955 R 1 RT 253.112157
1344 955 T 2 RT 63.819078
1345 956 R 1 RT 34.723305
1346 956 T 2 RT 23.174148
1347 957 R 1 RT 44.195532
1348 957 T 2 RT 90.627557
1349 958 R 1 RT 172.53421
1350 958 T 2 RT 21.767711
1351 959 R 1 RT 104.418557
1352 959 T 2 RT 132.784817
1353 960 R 1 RT 148.995496
1354 960 T 2 RT 72.25459
1355 961 R 1 RT 139.235947
1356 961 T 2 RT 21.048731
1357 962 R 1 RT 68.443055
1358 962 T 2 RT 107.741872
1359 963 R 1 RT 165.729851
1360 963 T 2 RT 62.650965
1361 964 R 1 RT 247.197188
1362 964 T 2 RT 37.688279
1363 965 R 1 RT 85.98977
1364 965 T 2 RT 99.35077
1365 966 R 1 RT 69.418449
1366 966 T 2 RT 17.996155
1367 967 R 1 RT 76.98232
1368 967 T 2 RT 27.032075
1369 968 R 1 RT 85.289183
1370 968 T 2 RT 45.368731
1371 969 R 1 RT 59.875173
1372 969 T 2 RT 25.37233
1373 970 R 1 RT 100.365754
1374 970 T 2 RT 54.21029
1375 971 R 1 RT 81.283211
1376 971 T 2 RT 39.810166
1377 972 R 1 RT 79.873567
1378 972 T 2 RT 57.122919
1379 973 R 1 RT 121.08553
1380 973 T 2 RT 40.406514
1381 974 R 1 RT 44.045074
1382 974 T 2 RT 33.226413
1383 975 R 1 RT 114.673124
1384 975 T 2 RT 17.796087
1385 976 R 1 RT 80.124046
1386 976 T 2 RT 37.736682
1387 977 R 1 RT 60.22591
1388 977 T 2 RT 102.943701
1389 978 R 1 RT 36.598551
1390 978 T 2 RT 86.611485
1391 979 R 1 RT 120.153601
1392 979 T 2 RT 80.772765
1393 980 R 1 RT 112.020149
1394 980 T 2 RT 17.684774
1395 981 R 1 RT 35.650606
1396 981 T 2 RT 74.788404
1397 982 R 1 RT 208.015452
1398 982 T 2 RT 24.713801
1399 983 R 1 RT 52.969681
1400 983 T 2 RT 54.812334
1401 984 R 1 RT 158.812733
1402 984 T 2 RT 29.611692
1403 985 R 1 RT 113.229607
1404 985 T 2 RT 34.999537
1405 986 R 1 RT 62.151407
1406 986 T 2 RT 108.580431
1407 987 R 1 RT 218.832947
1408 987 T 2 RT 165.297431
1409 988 R 1 RT 132.168555
1410 988 T 2 RT 66.855143
1411 989 R 1 RT 88.202967
1412 989 T 2 RT 129.654667
1413 990 R 1 RT 209.838281
1414 990 T 2 RT 61.007877
1415 991 R 1 RT 173.227324
1416 991 T 2 RT 97.753317
1417 992 R 1 RT 133.652768
1418 992 T 2 RT 40.359907
1419 993 R 1 RT 185.817376
1420 993 T 2 RT 24.437546
1421 994 R 1 RT 244.451413
1422 994 T 2 RT 33.922265
1423 995 R 1 RT 90.175789
1424 995 T 2 RT 47.07753
1425 996 R 1 RT 128.803679
1426 996 T 2 RT 102.542773
1427 997 R 1 RT 85.670869
1428 997 T 2 RT 45.720415
1429 998 R 1 RT 286.780345
1430 998 T 2 RT 73.954228
1431 999 R 1 RT 63.111898
1432 999 T 2 RT 13.300927
1433 1000 R 1 RT 55.80308
1434 1000 T 2 RT 50.057746
;
RUN;

ods graphics off;
PROC GLM data=pkdata;
CLASS Period Sequence Formulation Subject;
MODEL logCMAX = Sequence Subject(Sequence) Period Formulation/CLPARM ALPHA=0.1;
RANDOM Subject(Sequence) /TEST;
LSMEANS Formulation / PDIFF=control("R") CL ALPHA=0.1;
ESTIMATE 'T vs R' Formulation -1 1;
ods output LSMeanDiffCL=LSMeanDiffCL;
RUN;

PROC APPEND base=result data=work.lsmeandiffcl;
RUN;

DATA result (drop=i j Dependent Difference _Formulation LowerCL UpperCL);
set result;
LowerCI = exp(LowerCL)*100;
Diff = exp(Difference)*100;
UpperCI = exp(UpperCL)*100;
RUN;

[свернуть]